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Amphetamine is understood to inhibit monoamine oxidase, While the ability of amphetamine and its metabolites to inhibit a variety of P450 isozymes and other enzymes has not been adequately elucidated. In vitro experiments with human microsomes point out insignificant inhibition of CYP2D6 by amphetamine and minimal inhibition of CYP1A2, 2D6, and 3A4